Clinical relevance of alternative splicing

The unique phenomenon of alternative splicing is gathering concern due to its promising therapeutic potential. The human genome sequencing project suggests approximately 20,000-25,000 genes. Among these, about 35-60% of genes generate multiple mRNAs by alternative splicing mechanism and contribute to the diversity of the proteomic world. This ‘gene shortfall’ has ignited considerable interest i...

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Role of Aberrant Alternative Splicing in Cancer

Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...

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Types of Alternative Splicing

Alternative splicing events are classified into four main subgroups: (i) exon skipping (cassette exons), where the exon can be spliced out of the transcript together with its flanking introns; (ii) alternative 5�ss and (iii) 3�ss selection, which are the results of the recognition of two or more splice sites at one end of an exon; and (iv) intron retention, in wh...

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Types of Alternative Splicing

Alternative splicing events are classified into four main subgroups: (i) exon skipping (cassette exons), where the exon can be spliced out of the transcript together with its flanking introns; (ii) alternative 5�ss and (iii) 3�ss selection, which are the results of the recognition of two or more splice sites at one end of an exon; and (iv) intron retention, in wh...

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Types of Alternative Splicing

Alternative splicing events are classified into four main subgroups: (i) exon skipping (cassette exons), where the exon can be spliced out of the transcript together with its flanking introns; (ii) alternative 5�ss and (iii) 3�ss selection, which are the results of the recognition of two or more splice sites at one end of an exon; and (iv) intron retention, in wh...

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Clinical relevance of alternative splicing

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